IMI Interdisciplinary Mathematics InstituteCollege of Arts and Sciences

Targeting Nrf2 Against Heart Failure

  • Nov. 14, 2011
  • 1:30 p.m.
  • LeConte 312

Abstract

Cardiovascular diseases continue to be the first killer in USA. One of the major contributors to the death is the heart failure without any effective therapeutic approaches available. We have demonstrated that Nrf2, a master transcription factor of endogenous anti-oxidant defense system, serves as a negative regulator of maladaptive cardiac hypertrophy and dysfunction using Nrf2 knockout and Nrf2 cardiac specific transgenic mice. Pharmacological activation of Nrf2 with a novel synthesized derivate of triterpenoid protects against pressure overload-induced cardiac dysfunction in mice, revealing a new avenue of targeting Nrf2 pathway for the treatment of heart failure.

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