IMI Interdisciplinary Mathematics InstituteCollege of Arts and Sciences

Cell-based, Multiscale Model of Angiogenesis

  • Nov. 12, 2012
  • 2:30 p.m.
  • LeConte 312

Abstract

Angiogenesis, growth of new blood vessel from existing ones, requires an elaborate coordination between cell proliferation, migration, differentiation, and heterotypic cell-cell interactions. It is essential for mammalian development and plays a critical role in homeostasis, wound healing, and in the outcome of many pathologies including cancer. Modulation of vessel growth has been a target of therapeutic intervention in many diseases. Clear understanding of how vessels initiate, sprout, expand and loop to form a network can offer the potential for therapy in situations where enhanced or suppressed vascular growth is necessary. We have developed a cell-based, multiscale model for angiogenesis, integrating signaling network, cell dynamics and cell interactions, and tissue level chemical and biophysical microenvironment, in one framework. We applied this framework to model angiogenesis in retina during development as well as tumor induced angiogenesis. I will report our recent progresses.

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