IMI Interdisciplinary Mathematics InstituteCollege of Arts and Sciences

Cardiovascular Engineering and the Influence of Hemodynamics on Growth and Remodeling

  • April 21, 2014
  • 1 p.m.
  • LeConte 312

Abstract

Arteries have an active mechano-sensitive microstructure driven by complex cellular matrix interactions that respond to alterations in stress and stretch. Mechanical forces, transduced from the extra-cellular space, act on intra-cellular signaling cascades that influence gene expression. These cell-matrix interactions are responsible for differentiation, proliferation, and the synthesis/ removal of structurally significant proteins and signaling molecules. Thus blood vessel wall morphology depends strongly on the hemodynamic environment. In disease, injury, or aging the arterial microstructure may exhibit mal-adaptive remodeling eventually leading to failure scenarios that include hemorrhage or occlusion. The ability to accurately predict and correct vascular problems is paramount to improving clinical outcomes.

In this presentation, I’ll demonstrate a series of experiments using hemodynamically and genetically modified animals, study the temporal micro/macro structurally adaptations, and employ an analytical model of acute and predictive arterial response to stimulation. I will show the methodology and implementation to precisely control pulsatile hemodynamics to engineer desired vascular outcomes. In addition to providing a sound theoretical and experimental framework by which to study tissue adaptation, this work challenges the existing paradigm that vascular remodeling is based on augmentation of mean pressure and flow and proposes pulsatile (dynamic) influences as the driving factor.

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