IMI Interdisciplinary Mathematics InstituteCollege of Arts and Sciences

A multiscale model for cell sorting and heterogeneous tumor spheroid growth

  • April 7, 2017
  • 11 a.m.
  • LeConte 312

Abstract

In this talk, I will present a novel multiscale model for the study of heterogeneous spheroid growth in vitro. The entire spheroid is described by an ellipsoid-based model while nutrient and other environmental factors are treated as continua. The ellipsoid-based discrete component is capable of incorporating mechanical effects and deformability, while keeping a minimum set of free variables to describe complex shape variations. Our model and its implementations have been validated and applied to various studies such as cell sorting and tumor growth. In particular, it is highly suitable for the study of tumor spheroids in vitro whose size are normally less than 800 micrometer in diameter. The simulation results fit experimental observations very well.

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