Virus and T cell dynamics in HIV-infected individuals
- April 28, 2017
- 1 p.m.
- LeConte 312
HIV infection is still a serious health problem in the world. Effective combination therapy can control viral replication but cannot eradicate the virus. Mathematical models, combined with experimental data, have provided important insights into HIV dynamics and immune responses. In this talk, I will present some recent work on modeling HIV infection and treatment, such as HIV latency and persistence, viral blips, virus dynamics under different classes of drugs, treatment intensification with additional drugs, and the slow time scale of CD4+ T cell depletion in untreated patients. Model formulation, mathematical analysis, numerical simulation and comparison with data will be presented. Implications of modeling results for viral control strategies will also be discussed.